Platelet phospolipase A(2): toxicology and pharmacology

Cationic amphiphilic drugs from different pharmacological groups, i.e. prop ranolol, alprenolol, metipranolol and chloroquine, were found to significan tly: decrease the activity of stimulated blood platelet phospholipase A in vitro. In spits of the assumed phospholipidosis resulting from the inhibiti on of phospholipases induced by cationic amphiphilic drugs, this effect, wh ich might be responsible for inhibition of platelet aggregation, was consid ered to be favourable.