Streptozotocin diabetes induced gasrointestinal damage in rats: effect of stobadine

In rats with diabetes induced by streptozotocin, the effect of stobadine wa s studied on the extent of gastric damage, level of reduced glutathione and on the contractility of gastric smooth muscle. The results indicate that c hronic oral treatment with stobadine ill the highest daily dose used (63 mg /kg) almost completely suppressed the formation of spontaneous gastric lesi ons and increased the level of reduced glutathione in tile gastric mucosa. The contractile responses to 5-HT, acetylcholine, and noradrenaline of gast ric fundus circular smooth muscle suggest only marginal, not significant. a lterations in the actions of the individual stimulants in both control and diabetic rats.