Novel 5,5-disubstitutedpyrimidine-2,4,6-trione as selective MMP inhibitors

Authors
Foley, LH Palermo, R Dunten, P Wang, P
Citation
Lh. Foley et al., Novel 5,5-disubstitutedpyrimidine-2,4,6-trione as selective MMP inhibitors, BIOORG MED, 11(8), 2001, pp. 969-972
Citations number
12
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
8
Year of publication
2001
Pages
969 - 972
Database
ISI
SICI code
0960-894X(20010423)11:8<969:N5ASMI>2.0.ZU;2-3
Abstract
The 5.5-disubstitutedpyrimidine-2,4.6-trione represent a new class of MIL I P inhibitors showing selectivity for the gelatinases A and B, collagenase-3 , and human neutrophil collagenase. The SAR presented here is in good agree ment with an X-ray structure of compound 5 bound to the catalytic domain of stromelysin-1. While of the barbiturate structural class, compound 5 did n ot show any toxic or sedative effects. (C) 2001 Elsevier Science Ltd. All r ights reserved.