The program DOCK3.5 was used to search the Cambridge Structural Database fo
r novel inhibitors of Leishmanial dihydrofolate reductase. A number of comp
ounds were obtained and screened against the enzyme and against the intact
parasite Leishmania donovani and the related organisms Trypanosoma brucei a
nd Trypanosoma cruzi. The compounds screened showed weak activity in both t
he enzyme assays and the in vitro assays. (C) 2001 Elsevier Science Ltd. Al
l rights reserved.