Novel inhibitors of Leishmanial dihydrofolate reductase

Authors
Chowdhury, SF Di Lucrezia, R Guerrero, RH Brun, R Goodman, J Ruiz-Perez, LM Pacanowska, DG Gilbert, IH
Citation
Sf. Chowdhury et al., Novel inhibitors of Leishmanial dihydrofolate reductase, BIOORG MED, 11(8), 2001, pp. 977-980
Citations number
22
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
8
Year of publication
2001
Pages
977 - 980
Database
ISI
SICI code
0960-894X(20010423)11:8<977:NIOLDR>2.0.ZU;2-Q
Abstract
The program DOCK3.5 was used to search the Cambridge Structural Database fo r novel inhibitors of Leishmanial dihydrofolate reductase. A number of comp ounds were obtained and screened against the enzyme and against the intact parasite Leishmania donovani and the related organisms Trypanosoma brucei a nd Trypanosoma cruzi. The compounds screened showed weak activity in both t he enzyme assays and the in vitro assays. (C) 2001 Elsevier Science Ltd. Al l rights reserved.