Study of aminoglycoside-nucleic acid interactions by an HPLC method

Authors
Constantinou-Kokotou, V Karikas, G Kokotos, G
Citation
V. Constantinou-kokotou et al., Study of aminoglycoside-nucleic acid interactions by an HPLC method, BIOORG MED, 11(8), 2001, pp. 1015-1018
Citations number
21
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
8
Year of publication
2001
Pages
1015 - 1018
Database
ISI
SICI code
0960-894X(20010423)11:8<1015:SOAAIB>2.0.ZU;2-I
Abstract
The interactions of a number of aminoglycoside antibiotics with tRNA and DN A were studied by an HPLC method, based on tRNA and DNA peak size exclusion . Among the compounds studied (deoxystreptamine. neamine, neomycin B, kanam ycin A, gentamicin A, netilmicin. streptomycin, and the synthetic neamine a nalogue BKN3), neomycin B and the synthetic analogue of neamine were proved to be the most potent binders, (C) 2001 Elsevier Science Ltd. All rights r eserved.