Structure determination and comparison of BM567, a sulfonylurea, with terbogrel, two compounds with dual action, thromboxane receptor antagonism and thromboxane synthase inhibition

Authors
Michaux, C Rolin, S Dogne, JM Durant, F Masereel, B Delarge, J Wouters, J
Citation
C. Michaux et al., Structure determination and comparison of BM567, a sulfonylurea, with terbogrel, two compounds with dual action, thromboxane receptor antagonism and thromboxane synthase inhibition, BIOORG MED, 11(8), 2001, pp. 1019-1022
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
8
Year of publication
2001
Pages
1019 - 1022
Database
ISI
SICI code
0960-894X(20010423)11:8<1019:SDACOB>2.0.ZU;2-Z
Abstract
BM567, a sulfonylurea compound-whose crystal structure is here discussed-an d terbogrel are both thromboxane receptor antagonists and thromboxane synth ase inhibitors. In this paper. their crystallographic and electronic struct ures are compared and lead to new synthesis prospects among the sulfonylurc a series. (C) 2001 Elsevier Science Ltd. All rights reserved.