The discovery of RFI-641 as a potent and selective inhibitor of the respiratory syncytial virus

Authors
Nikitenko, AA Raifeld, YE Wang, TZ
Citation
Aa. Nikitenko et al., The discovery of RFI-641 as a potent and selective inhibitor of the respiratory syncytial virus, BIOORG MED, 11(8), 2001, pp. 1041-1044
Citations number
14
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
8
Year of publication
2001
Pages
1041 - 1044
Database
ISI
SICI code
0960-894X(20010423)11:8<1041:TDORAA>2.0.ZU;2-S
Abstract
The design and synthesis of a new potent and selective inhibitor of the res piratory syncytial virus are described. This compound, RFI-641, emerged Fro m analysis of the structure-activity relationship in a series of biphenyl t riazine anionic compounds possessing specific anti-RSV activity. The key sy nthetic step involves coupling of diaminobiphenyl 11 with two equivalents o f chlorotriazine 10 under microwave conditions. RFI-641 inhibited RSV in vi tro and in vivo models. (C) 2001 Elsevier Science Ltd. All rights reserved.