Novel, lipophilic derivatives of 2,5-dideoxy-2,5-imino-D-mannitol (DMDP) are powerful beta-glucosidase inhibitors

Authors
Wrodnigg, TM Withers, SG Stutz, AE
Citation
Tm. Wrodnigg et al., Novel, lipophilic derivatives of 2,5-dideoxy-2,5-imino-D-mannitol (DMDP) are powerful beta-glucosidase inhibitors, BIOORG MED, 11(8), 2001, pp. 1063-1064
Citations number
9
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
8
Year of publication
2001
Pages
1063 - 1064
Database
ISI
SICI code
0960-894X(20010423)11:8<1063:NLDO2(>2.0.ZU;2-Q
Abstract
Novel derivatives of the D-glucosidase inhibitor 2,5-dideoxy-2,5-imino-D-ma nnitol bearing lipophilic aliphatic or aromatic amides attached to C-l have been found to inhibit P-glucosidase from Agrobacterium sp. in the nanomola r range. One of them, a coumarin derivative. ranks amongst the most active compounds in the class of reversible glycosidase inhibitors of the iminoald itol type. (C) 2001 Elsevier Science Ltd. All rights reserved.