1,2,5-thiadiazole derivatives are potent and selective ligands at human 5-HT1A receptors

Authors
Sabb, AL Vogel, RL Kelly, MG Palmer, Y Smith, DL Andree, TH Schechter, LE
Citation
Al. Sabb et al., 1,2,5-thiadiazole derivatives are potent and selective ligands at human 5-HT1A receptors, BIOORG MED, 11(8), 2001, pp. 1069-1071
Citations number
7
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
8
Year of publication
2001
Pages
1069 - 1071
Database
ISI
SICI code
0960-894X(20010423)11:8<1069:1DAPAS>2.0.ZU;2-8
Abstract
Amino acid derivatives of 1,2,5-thiadiazol-3-yl-piperazine related to (+)-W AY-100135 and WAY-100635 are potent 5-HT1A receptor agonists and antagonist s, which have selective affinity for 5-HT1A receptors versus alpha (1) and dopamine (D-2. D-3. and D-4) receptors (C) 2001 Elsevier Science Ltd. All r ights reserved.