2-(3,5-dimethylphenyl)tryptamine derivatives that bind to the GnRH receptor

Authors
Lin, P Marino, D Lo, JL Yang, YT Cheng, K Smith, RG Fisher, MH Wyvratt, MJ Goulet, MT
Citation
P. Lin et al., 2-(3,5-dimethylphenyl)tryptamine derivatives that bind to the GnRH receptor, BIOORG MED, 11(8), 2001, pp. 1073-1076
Citations number
17
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
8
Year of publication
2001
Pages
1073 - 1076
Database
ISI
SICI code
0960-894X(20010423)11:8<1073:2DTBTT>2.0.ZU;2-B
Abstract
A series of 2-(3.5-dimethylphenyl)tryptamine derivatives was prepared and e valuated on a rat gonadotropin releasing hormone receptor assay. Some para- substituents on the 4-phenylbutyl side chain attached to the tryptamine nit rogen led to com pounds with potent GnRH receptor binding. The study has he lped define structural requirements for GnRH receptor binding for the 2-ary ltryptamine GnRH antagonists. (C) 2001 Elsevier Science Ltd. All rights res erved.