Synthesis and structure-activity relationships of guan analogues as phosphodiesterase 7 (PDE7) inhibitors

Authors
Barnes, MJ Cooper, N Davenport, RJ Dyke, HJ Galleway, FP Galvin, FCA Gowers, L Haughan, AF Lowe, C Meissner, JWG Montana, JG Morgan, T Picken, CL Watson, RJ
Citation
Mj. Barnes et al., Synthesis and structure-activity relationships of guan analogues as phosphodiesterase 7 (PDE7) inhibitors, BIOORG MED, 11(8), 2001, pp. 1081-1083
Citations number
17
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
8
Year of publication
2001
Pages
1081 - 1083
Database
ISI
SICI code
0960-894X(20010423)11:8<1081:SASROG>2.0.ZU;2-R
Abstract
The synthesis of a novel series of guanine analogues is reported. The compo unds have been assessed in vitro and some analogues have been found to be i nhibitors of phosphodiesterase type 7 (PDE7). (C) 2001 Elsevier Science Ltd . All rights reserved.