Dimeric L-Dopa derivatives as potential prodrugs

Authors
Di Stefano, A Mosciatti, B Cingolani, GM Giorgioni, G Ricciutelli, M Cacciatore, I Sozio, P Claudi, F
Citation
A. Di Stefano et al., Dimeric L-Dopa derivatives as potential prodrugs, BIOORG MED, 11(8), 2001, pp. 1085-1088
Citations number
12
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
8
Year of publication
2001
Pages
1085 - 1088
Database
ISI
SICI code
0960-894X(20010423)11:8<1085:DLDAPP>2.0.ZU;2-6
Abstract
A series of dimeric derivatives ( +)-1, and ( +)-2. and (+)-3a-d of L-Dopa diacetyl esters was synthesized and evaluated as potential L-Dopa prodrugs with improved physicochemical properties. All the new compounds showed chem ical stability in aqueous buffer solutions (pH 1.3 and 7.4). A relatively s low release of r-Dopa in human plasma was observed. (C) 2001 Elsevier Scien ce Ltd. All rights reserved.