Novel alpha-hydroxyethyl-polystyrene, alpha-chloroethyl-polystyrene and alpha-amino-oxyethyl-polystyrene linkers on the Multipin (TM) solid Support for solid-phase organic synthesis

Authors
Bui, CT Maeji, NJ Bray, AM
Citation
Ct. Bui et al., Novel alpha-hydroxyethyl-polystyrene, alpha-chloroethyl-polystyrene and alpha-amino-oxyethyl-polystyrene linkers on the Multipin (TM) solid Support for solid-phase organic synthesis, BIOTECH BIO, 71(2), 2000, pp. 91-93
Citations number
15
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
BIOTECHNOLOGY AND BIOENGINEERING
ISSN journal
00063592 → ACNP
Volume
71
Issue
2
Year of publication
2000
Pages
91 - 93
Database
ISI
SICI code
0006-3592(2000)71:2<91:NAAAA>2.0.ZU;2-0
Abstract
A simple method for the generation of th ree novel linkers, alpha -hydroxye thyl-polystyrene, alpha -chtoroethyl-polystyrene and alpha -amino-oxyethyl- polystyrene on Multipin supports (SynPhase (TM) Crowns) has been developed. Applications of these linkers have been successfully demonstrated for soli d-phase synthesis of dipeptide, oxime, and hydroxamic acid compounds in goo d yields and purities. (C) 2000 John Wiley & Sons, Inc.