A selenide linker for "traceless" solid-phase organic synthesis

Authors
Li, ZG Kulkarni, BA Ganesan, A
Citation
Zg. Li et al., A selenide linker for "traceless" solid-phase organic synthesis, BIOTECH BIO, 71(2), 2000, pp. 104-106
Citations number
23
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
BIOTECHNOLOGY AND BIOENGINEERING
ISSN journal
00063592 → ACNP
Volume
71
Issue
2
Year of publication
2000
Pages
104 - 106
Database
ISI
SICI code
0006-3592(2000)71:2<104:ASLF"S>2.0.ZU;2-P
Abstract
4-Bromophenethyl alcohol was protected as the THP ether, followed by reacti on with magnesium and selenium to give the corresponding diselenide. Ether deprotection provides a diselenide diol, which is attached to solid-phase r esins. The polymer-bound selenide anion is then generated, and functions as a traceless linker for electrophiles such as alkyl halides. (C) 2001 John Wiley & Sons, Inc.