Azorellane diterpenoids from Lareta acaulis, and its toxoplasmacidal activity

Authors
Loyola, LA Borquez, J Morales, G Araya, J Gonzalez, J Neira, I Sagua, H San-Martin, A
Citation
La. Loyola et al., Azorellane diterpenoids from Lareta acaulis, and its toxoplasmacidal activity, BOL SOC CH, 46(1), 2001, pp. 9-13
Citations number
8
Categorie Soggetti
Chemistry
Journal title
BOLETIN DE LA SOCIEDAD CHILENA DE QUIMICA
ISSN journal
03661644 → ACNP
Volume
46
Issue
1
Year of publication
2001
Pages
9 - 13
Database
ISI
SICI code
0366-1644(200103)46:1<9:ADFLAA>2.0.ZU;2-K
Abstract
In addition to azorellanol a new diterpenoid 7-deacetylazorellanol, has bee n isolated from the aerial parts of Laretia acaulis (Cav.) Gill et Hook (Um belliferae), its structure was based on spectroscopic comparison with azore llanol and chemical grounds. Azorellanol and 7-deacetylazorellanol showed m arked inhibitor activity against trophozoites of protozoan parasite Toxopla sma gondii. The 50 % inhibitory dose for azorellanol was calculated in 54 m uM and for 7-deacetylazorellanol was 42 muM.