Two dogs were diagnosed with enterotoxigenic Clostridium perfringens-associ
ated diarrhea. Diarrhea was responsive to antimicrobial therapy, but recurr
ed after treatment was ceased. Clostridium perfringens enterotoxin was pres
ent in feces during diarrheic episodes but not when feces were normal. Both
dogs responded to a prolonged course of oral cephalexin and dietary modifi
cation.