Spacer arm influence on glucidoamphiphile compound properties

We prepared glucidoamphiphile derivatives from D-glucose, D-galactose and x ylitol. in which the glucidic moiety and the hydrophobic alkyl chain are se parated by spacer arm E (E = glyceryl, (OEt)(2)-alpha -polypropyleneglycyl and butyloxy). Their amphiphile characteristics are compared to those of th e corresponding analogs 3-O-alkyl-D-glucopyranoses. 6-O-alkyl-D-galactopyra noses and 1-O-alkyl-D,L-xylitols. We discussed the spacer arm influence on hydrophobic lipophilic balance (HLB), critical micellar concentration (CMC) , water solubility (S-w) and phase transition temperatures of thermotropic and lyotropic mesophases. (C) 2001 Elsevier Science Ltd. All rights reserve d.