Bioanalytical solid-phase extraction: A classic in a new, tailor-made garment

In bioanalytical HPLC, optimization of sample pretreatment should be direct ed towards improved selectivity, high sample through-put and total automati on with simultaneous cost-reduction and improvment of the analytical qualit y. These requirements can be accomplished by integrating the extractive sam ple clean-up process (Solid-Phase Extraction; SPE) into the HPLC-system. Fo r this purpose, tailor-made adsorbents (Restricted Access Materials, RAM; M olecular imprinted Polymers, MIP) are used as precolumn packings.