Fibromyalgia syndrome and serotonin

Citation
Mny. Alnigenis et P. Barland, Fibromyalgia syndrome and serotonin, CLIN EXP RH, 19(2), 2001, pp. 205-210
Citations number
42
Categorie Soggetti
Rheumatology,"da verificare
Journal title
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
ISSN journal
0392856X → ACNP
Volume
19
Issue
2
Year of publication
2001
Pages
205 - 210
Database
ISI
SICI code
0392-856X(200103/04)19:2<205:FSAS>2.0.ZU;2-5
Abstract
Although disturbances in the musculo-skeletal system, in the neuroendocrine system and in the central nervous system (CNS) have been implicated in the pathophysiology of fibromyalgia syndrome (FMS), the primary mechanisms und erlying the etiopathogenesis of FMS remain elusive. It has been postulated that disturbances in serotonin metabolism and transmission, along with dist urbances in several other chemical pain mediators, are present in patients with FMS. In this article we review published studies on the pathophysiolog ical role of serotonin in FMS. Although studies that indirectly measured th e function of serotonin in the CNS in FMS revealed some abnormalities in th e metabolism and transmission of serotonin, the role of serotonin in the pa thophysiology of syndrome remains inconclusive and warrants more studies.