Combinatorial biosynthesis of polyketides and nonribosomal peptides

Authors
Staunton, J Wilkinson, B
Citation
J. Staunton et B. Wilkinson, Combinatorial biosynthesis of polyketides and nonribosomal peptides, CURR OP C B, 5(2), 2001, pp. 159-164
Citations number
46
Categorie Soggetti
Biochemistry & Biophysics
Journal title
CURRENT OPINION IN CHEMICAL BIOLOGY
ISSN journal
13675931 → ACNP
Volume
5
Issue
2
Year of publication
2001
Pages
159 - 164
Database
ISI
SICI code
1367-5931(200104)5:2<159:CBOPAN>2.0.ZU;2-S
Abstract
The engineering of polyketide biosynthesis has begun to provide robust targ eted libraries for screening against pharmaceutically relevant targets. New technologies that offer methodology for the rapid generation of more struc turally diverse libraries have now been demonstrated.