Lanthanide-mediated DNA hydrolysis

Authors
Franklin, SJ
Citation
Sj. Franklin, Lanthanide-mediated DNA hydrolysis, CURR OP C B, 5(2), 2001, pp. 201-208
Citations number
48
Categorie Soggetti
Biochemistry & Biophysics
Journal title
CURRENT OPINION IN CHEMICAL BIOLOGY
ISSN journal
13675931 → ACNP
Volume
5
Issue
2
Year of publication
2001
Pages
201 - 208
Database
ISI
SICI code
1367-5931(200104)5:2<201:LDH>2.0.ZU;2-#
Abstract
Lanthanide ions are remarkably effective catalysts for the hydrolytic cleav age of phosphate ester bonds, including the robust bonds of DNA. This makes Ln(lll) and Ce(IV) ions attractive candidates for developing selective and efficient artificial nucleases, which could have many biochemical and clin ical applications. Both small-molecule-based and biopolymer-based lanthanid e complexes are being pursued.