Dimorphism in fungal pathogens: Candida albicans and Ustilago maydis - similar inputs, different outputs

The ability to switch between a yeast-like form and a filamentous form is a n extended characteristic among several fungi. In pathogenic fungi, this ca pacity has been correlated with virulence because along the infection proce ss, dimorphic transitions are often required. Two well-known organisms for which dimorphism have been studied are the pathogenic fungi Candida albican s and Ustilago maydis, which infect mammals and corn, respectively. In both cases, several signal transduction pathways have been defined, Not surpris ingly these pathways are similar to the well-known pathways involved in the pseudohyphal differentiation that some Saccharomyces cerevisiae diploid st rains show when nutrients are starved, However, in spite of similarities at the molecular level, strikingly, fungi use similar pathways to respond to environmental inputs, but with differing outcomes.