Effect of electromagnetic fields on bone mineral density and biochemical markers of bone turnover in osteoporosis: A single-blind, randomized pilot study

Background: The effect of pulsed electromagnetic fields (PEMFs) on bone for mation and remodeling has been evaluated in several studies in the last 30 years, but the results of these studies have been equivocal. Objective: The aim of this study was to investigate the effects of PEMFs on bone mineral density (BMD) and the biochemical markers of bone turnover in patients with postmenopausal osteoporosis. Methods: In this single-blind, randomized study, 40 outpatients were expose d to 100-Hz PEMFs (n = 20) or to a placebo electromagnetic field (n = 20) f or 60 minutes per day, 3 times a week for 3 months. BMD was measured at bas eline and at the end of treatment, and biochemical markers of bone metaboli sm were measured at baseline, after 3 months' treatment, and 1 month after treatment cessation. Results: Treatment with PEMFs did not cause a significant increase in BMD i n either group. However, in the group treated with 100-Hz PEMFs, a signific ant increase in serum osteocalcin and serum procollagen type I C-terminal p ropeptide was observed during treatment (P < 0.001 vs baseline); these para meters returned to baseline values 1 month after the end of treatment. Conclusions: These findings suggest that PEMFs may stimulate osteogenesis, possibly by increasing osteoblastic activity, in postmenopausal women with osteoporosis.