Pigmented Paget's disease of the male breast: Report of a case

An 83-year-old man with pigmented Pager's disease of the breast is reported . He had a blackish swollen right nipple with bloody discharge that lasted for 8 months. Histopathology of the lesion disclosed intraepidermal and der mal atypical cells forming small clusters and underlying intraductal carcin oma. Melanocytes were dispersed in the epi dermis. Dermal melanophages were also detected. The atypical cells were positive for carcinoembryonic antig en, human-milk fat globule protein and a recently described new antigen, RC AS-1, but negative for S-100 or HMB-45. We diagnosed this case as Paget's d isease of the male breast. Paget's disease of the breast is usually nonpigm ented and occurs almost exclusively in women. Pigmented Paget's disease of the male breast is extremely rare, and only a few cases have been reported. Albeit rare, pigmented Paget's disease has to be included in the different ial diagnosis of pigmented lesions of the nipple. Copyright (C) 2001 S. Kar ger AG, Basel.