Gastrointestinal involvement is frequent in patients with systemic sclerosi
s (SSc); however, studies on the proximal stomach and its regulation are la
cking. It has been hypothesized that the primary event in the pathogenesis
of gastrointestinal involvement in SSc is an early neural lesion. This stud
y investigates proximal stomach function and its relation to autonomic nerv
e function in SSc, Twenty SSc patients classified in to clinical subsets, u
nderwent measurement of proximal stomach function with and without glucagon
by electronic barostat and an assessment of autonomic nerve function. SSc
patients were not significantly different from 11 controls for gastric comp
liance (59.5 +/- 5.0 vs 47.7 +/- 4.2 ml/mm Hg. P = 0.1). The pressure-volum
e curves in each participant with and without glucagon were significantly d
ifferent (P ( 0.001). A significant positive association was found between
gastric compliance and autonomic nerve function (P < 0.05). The change in g
astric compliance during glucagon administration was significant associated
with autonomic function (P ( 0.05). The perception cumulative scores did n
ot differ between SSc patients and control subjects (P = 0.2). In conclusio
n, proximal stomach function is associated with autonomic nerve function in
SSc patients. This confirms the frequent association of motility disorders
with autonomic dysfunction in SSc.