R. Morrone et al., Resolution of racemic acids by irreversible lipase-catalyzed esterification in organic solvents, EUR J ORG C, (8), 2001, pp. 1441-1443
The reversible nature of the direct esterification of acids with alcohols L
imits the use of this process in the biocatalytic kinetic resolution of chi
ral acids. A new irreversible procedure. using orthoesters, has been develo
ped.