Solitary fibrous tumour of the urinary bladder with expression of bcl-2, CD34, and insulin-like growth factor type II

We describe a solitary fibrous tumour of the urinary bladder wall removed f rom a 50-year-otd man with a history of pelvic pain, dysuria, and urinary b leeding. Anamnesis revealed a weight increase during the preceding 3 months , but no apparent episodes of biochemical hypoglycaemia or hormonal abnorma lities. The patient is alive and well 18 months after surgery, Pathological examination revealed a 6.5-cm well-circumscribed nodular mass composed of uniform spindle cells arranged in bundles and fascicles with varying amount s of collagen and a typical haemangiopericytoma-like vascular pattern. The tumour cells were positive for bcl-2, CD34, and vimentin and ultrastructura lly showed mesenchymal-myofibroblastic traits. These cells produced insulin -like growth factor type II mRNA as demonstrated by non-isotopic in situ hy bridization. This rare case with a solitary fibrous tumor suggests that ins ulin-like growth factor type II could join CD34 and bcl-2 as markers for po stoperative differential diagnosis, Copyright (C) 2001 S. Karger AG, Baser.