Intraadrenal mechanisms of DHEA regulation: A hypothesis for adrenopause

Authors
Alesci, S Bornstein, SR
Citation
S. Alesci et Sr. Bornstein, Intraadrenal mechanisms of DHEA regulation: A hypothesis for adrenopause, EXP CL E D, 109(2), 2001, pp. 75-82
Citations number
99
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
ISSN journal
09477349 → ACNP
Volume
109
Issue
2
Year of publication
2001
Pages
75 - 82
Database
ISI
SICI code
0947-7349(2001)109:2<75:IMODRA>2.0.ZU;2-Q
Abstract
Dehydroepiandrosterone (DHEA) and its sulfate metabolite DHEAS are the majo r androgens secreted by the human adrenal gland. The specific control of th ese hormones remains unclear. While ACTH is a potent stimulator of DHEA sec retion, other factors both systemic and local have been involved in adrenal androgen control. Here we review the extra and intra-adrenal regulation of DHEA and propose a hypothetical model for adrenal senescence.