S15176 and S16950 interaction with Cyclosporin A antiproliferative effect on cultured human lymphocytes

S15176 and S16950 are trimetazidine derivatives that antagonize more strong ly than tile parent drug mitochondrial toxicity, which leads to cellular hy poxia and nephrotoxicity in kidneys experimentally exposed to cyclosporin A . We have investigated whether every derivative might interact or not with the inhibitory effect of Cyclosporin A on the proliferation of cultured hum an lymphocytes. S15176 significantly increased the antilymphoproliferative effect of Cyclosporin A, whereas S15176 by itself neither displayed any ant ilymphoproliferative effect, nor did it induce any apoptotic process in cul tured human lymphocytes, The effect of S16950 was not significant.