A new approach to antiplatelet therapy: Inhibitor of GPIb/V/IX-vWF interaction

Authors
Ikeda, Y Handa, M Murata, M Goto, S
Citation
Y. Ikeda et al., A new approach to antiplatelet therapy: Inhibitor of GPIb/V/IX-vWF interaction, HAEMOSTASIS, 30, 2000, pp. 44-52
Citations number
17
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
HAEMOSTASIS
ISSN journal
03010147 → ACNP
Volume
30
Year of publication
2000
Supplement
3
Pages
44 - 52
Database
ISI
SICI code
0301-0147(2000)30:<44:ANATAT>2.0.ZU;2-R
Abstract
Evidence has been presented that the interaction between von Willebrand fac tor (VWF) and its platelet membrane receptor, the GPIb/V/IX complex, plays an important role in the pathogenesis of arterial thrombosis, A monoclonal antibody against the Al domain of VWF has been shown to inhibit thrombus fo rmation in the animal model of arterial thrombosis, Based upon these findin gs, a new approach to treating arterial thrombosis has been proposed by int ervening in the interaction between VWF and platelet. Copyright (C) 2001 S. Karger AG, Basel.