Thiazolidinyl-triazinoquinazolines as potent anti-inflammatory agents

Some new 5-(5'-substituted-aryl-2'-oxo-4'-thiazolidin-1'-yl)amino-4-phenyl- 2-methyl-10-bromo-[1,2,4]triazino[2,3c]quinazolines have been synthesized b y [1,5]cyclocondensation of thiolactic acid with 5-arylidene hydrazino-4-ph enyl-2-methyl-10-bromo-[1,2,4] triazino [2,3-c] quinazolines. All the compo unds of the series have been screened for their antiinflammatory activity. The most potent compound of the series 5-(5'-p-dimethylaminophenyl-2'-oxo-4 '-thiazolidin-1'-yl)amino-4-phenyl-2-methyl-10-bromo-[1,2,4] triazino[2,3-c ]quinazolines has shown 48.93% activity at a dose of 50 mg/kg p.o. The stru ctures of the products have been delineated by chemical reactions, elementa l analysis and spectral studies.