Screening of natural products for new leads as inhibitors of I kappa B alpha kinase: 2-hydroxy-6-substituted benzoic acids from plant extracts

Authors
Ramakrishna, NVS Jain, AK Kota, S Kumar, EKSV Kalakoti, S Gupte, RD Panicker, RB Vadlamudi, RVSV
Citation
Nvs. Ramakrishna et al., Screening of natural products for new leads as inhibitors of I kappa B alpha kinase: 2-hydroxy-6-substituted benzoic acids from plant extracts, I J CHEM B, 40(4), 2001, pp. 345-347
Citations number
9
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
ISSN journal
03764699 → ACNP
Volume
40
Issue
4
Year of publication
2001
Pages
345 - 347
Database
ISI
SICI code
0376-4699(200104)40:4<345:SONPFN>2.0.ZU;2-C
Abstract
2-Hydroxy-6-pentadecylbenzoic acid(1) 1,2-hydroxy-6-(8,11-pentadecadienyl)b enzoic acid(2) 2 and 2-hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid(2) 3 have been isolated from the crude extracts of plants from Anacardiaceae f amily by bioactive guided purification. Compound 1 has been isolated from p et, ether extract of twigs of Rhus semialata and 2, 3 from CH2Cl2-MeOH (1:1 ) extract of the dried pericarp of the fruits of Anacardium occidentale. Al l the three compounds show good I kappaB alpha kinase inhibitory activity.