Dissociation of infectivity and pathogenicity in Borrelia burgdorferi

Authors
Thomas, V Anguita, J Samanta, S Rosa, PA Stewart, P Barthold, SW Fikrig, E
Citation
V. Thomas et al., Dissociation of infectivity and pathogenicity in Borrelia burgdorferi, INFEC IMMUN, 69(5), 2001, pp. 3507-3509
Citations number
34
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
69
Issue
5
Year of publication
2001
Pages
3507 - 3509
Database
ISI
SICI code
0019-9567(200105)69:5<3507:DOIAPI>2.0.ZU;2-3
Abstract
Clonal Borrelia burgdorferi N40 (cN40) passaged 75 times in vitro (N40-75) infects mice but does not cause disease. N40-75 passaged 45 times further i n vitro (N40-120),vas no longer infectious and lacked genes encoded on line ar plasmids 38 and 28-1, among other differences. These data suggest that B . burgdorferi cN40, N40-75. and N40-120 have distinct phenotypes that can b e used to dissect the genetic elements responsible for pathogenicity and in fectivity.