Pneumolysin potentiates production of prostaglandin E-2 and leukotriene B-4 by human neutrophils

Authors
Cockeran, R Steel, HC Mitchell, TJ Feldman, C Anderson, R
Citation
R. Cockeran et al., Pneumolysin potentiates production of prostaglandin E-2 and leukotriene B-4 by human neutrophils, INFEC IMMUN, 69(5), 2001, pp. 3494-3496
Citations number
10
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
69
Issue
5
Year of publication
2001
Pages
3494 - 3496
Database
ISI
SICI code
0019-9567(200105)69:5<3494:PPPOPE>2.0.ZU;2-2
Abstract
Exposure to pneumolysin (8.37 and 41.75 ng/ml) caused a calcium-dependent i ncrease in the generation of prostaglandin E-2 and leukotriene B-4 by both resting and chemoattractant-activated human neutrophils in vitro. These int eractions of pneumolysin with neutrophils may result in dysregulation of in flammatory responses during pneumococcal infection.