Passive immunization with melanin-binding monoclonal antibodies prolongs survival of mice with lethal Cryptococcus neoformans infection

Authors
Rosas, AL Nosanchuk, JD Casadevall, A
Citation
Al. Rosas et al., Passive immunization with melanin-binding monoclonal antibodies prolongs survival of mice with lethal Cryptococcus neoformans infection, INFEC IMMUN, 69(5), 2001, pp. 3410-3412
Citations number
9
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
69
Issue
5
Year of publication
2001
Pages
3410 - 3412
Database
ISI
SICI code
0019-9567(200105)69:5<3410:PIWMMA>2.0.ZU;2-S
Abstract
Passive immunization with monoclonal antibodies (MAbs) to melanin prolonged the survival of and reduced the fungal burden in Cryptococcus neoformans-i nfected mice in comparison to controls, MAbs to melanin reduced the growth rate of in vitro-melanized C. neoformans cells, suggesting a new mechanism of antibody-mediated protection.