Assessing vascular permeability during experimental cerebral malaria by a radiolabeled monoclonal antibody technique

Authors
van der Heyde, HC Bauer, P Sun, G Chang, WL Yin, LJ Fuseler, J Granger, DN
Citation
Hc. Van Der Heyde et al., Assessing vascular permeability during experimental cerebral malaria by a radiolabeled monoclonal antibody technique, INFEC IMMUN, 69(5), 2001, pp. 3460-3465
Citations number
38
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
69
Issue
5
Year of publication
2001
Pages
3460 - 3465
Database
ISI
SICI code
0019-9567(200105)69:5<3460:AVPDEC>2.0.ZU;2-P
Abstract
Vascular endothelial integrity, assessed by Evans blue dye extrusion and ra diolabeled monoclonal antibody leakage, was markedly compromised in the bra in, lung, kidney, and heart during Plasmodium berghei infection, a well-rec ognized model fur human cerebral malaria. The results for vascular permeabi lity from both methods were significantly (P < 0.001) related.