Studies of different aspects of the pole of protein kinase C in mast cells

Mast cells induce the inflammatory process when their Fc epsilon RI recepto rs aggregate in response to an antigen binding to immunoglobulin E. Direct interactions between Fc epsilon RI receptor cytoplasmic domains and various intracellular proteins initiate diverse signal transduction pathways resul ting in the immediate release of proinflammatory agents, A delayed response also occurs that includes the release of various cytokines, It is clear th at the activation of kinases, such as protein kinase C (PKC), is a requirem ent for both the early and delayed responses of this inflammatory process. In this review we present the results of various studies investigating the role of PKC isozymes in mast cells. Copyright (C) 2001 S. Karger AG,Basel.