Sesaminol from sesame seed induces apoptosis in human lymphoid leukemia Molt 4B cells

Authors
Miyahara, Y Hibasami, H Katsuzaki, H Imai, K Osawa, T Ina, K Komiya, T
Citation
Y. Miyahara et al., Sesaminol from sesame seed induces apoptosis in human lymphoid leukemia Molt 4B cells, INT J MOL M, 7(5), 2001, pp. 485-488
Citations number
10
Categorie Soggetti
Medical Research General Topics
Journal title
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
ISSN journal
11073756 → ACNP
Volume
7
Issue
5
Year of publication
2001
Pages
485 - 488
Database
ISI
SICI code
1107-3756(200105)7:5<485:SFSSIA>2.0.ZU;2-F
Abstract
The exposure of human lymphoid leukemia Molt 4B cells to sesaminol, a compo nent of sesame oil led to both growth inhibition and the induction of apopt osis. Morphological change showing apoptotic bodies was observed in the cel ls treated with sesaminol. The fragmentation of DNA by sesaminol to oligonu cleosomal-sized fragments that are characteristics of apoptosis was observe d to be concentration- and time-dependent. These findings suggest that grow th inhibition of Molt 4B cells by sesaminol results from the induction of a poptosis in the cells.