Intranasal bioavailability of buprenorphine in rabbit correlated to sheep and man

The purpose of the present study of buprenorphine is to add information abo ut the correlation between various animal models and nasal bioavailabilitie s in man. PEG 300 was added to one formulation to study whether the additio n of the co-solvent results in the same absorption pattern as seen for shee p. The bioavailability of intranasal buprenorphine 0.6 mg in PEG 300 and 5% dextrose was assessed in a cross-over study in six rabbits. The mean bioav ailabilities, T-max and C-max were 46% (S.D. +/- 13) and 53% (S.D. +/- 17), 8 and 12 min, 28 and 27 ng/ml for 30% PEG 300 and 5% dextrose, respectivel y. No significant differences were found between the nasal buprenorphine fo rmulations. The bioavailabilities in rabbit and sheep, respectively, were a pproximate to2.5 and four times higher than for man. The absorption rate wa s faster for rabbit and sheep than for man. It appears that rabbit and shee p bioavailability differ from humans, especially with respect to rate. PEG 300 do not increase the bioavailability of buprenorphine. (C) 2001 Elsevier Science B.V. All rights reserved.