In vitro activity of telithromycin (HMR 3647) against 502 strains of anaerobic bacteria

In a previous study, we compared HMR 3004 with azithromycin, clarithromycin , erythromycin and roxithromycin against 502 anaerobic bacteria using NCCLS -approved procedures, This report extends this study by reporting the activ ity of telithromycin (HMR 3647) against these strains, Telithromycin inhibi ted 10% of Bacteroides fragilis, 50% of other B. fragilis group organisms a nd 93% of other Bacteroides spp, Telithromycin inhibited all Porphyromonas spp, and 98% of Prevotella spp. Activity against Bilophila wadsworthia (85- 96%) was excellent, Telithromycin was not active against the Fusobacterium mortiferum/varium group, Telithromycin inhibited 100% of Clostridium perfri ngens, 46-56% of Clostridium difficile and Clostridium ramosum and approxim ately 90% of non-spore-forming Gram-positive bacilli.