Poly(ethylene terephthalate) yarn with antibacterial properties

Poly(ethylene terephthalate) (PET) yarn with grafted poly(acrylic acid) (po ly(AA)) was loaded with [6R-[6 alpha .7 beta (Z)]]-7-[[2-amino-3-thiazolyl) (methoxy-imino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dio xo- 1,2,4-triazin-3-yl)thio]-methyl]-5-thia-1-rizabicyclo[4.2.0] oct-2-ene- 2-carboxylic acid (Lendacin), a cephalosporin-type antibiotic. Immobilizati on of Lendacin was due to ionic interactions. Drug loading was varied from 0.61 to 5.29% wt/wt. The release of Lendacin from the modified PET fibers t o water was monitored for 550 h. Variations of Lendacin concentration in wa ter were approximated with a double exponential equation (C-L = C-infinity{ a[1 - exp(-k(1)tau)] + b[1 - exp(-k(2)tau)]}) describing fast initial burst followed by slow release of Lendacin. In vitro studies revealed that the d rug loaded fibers were bioactive against Staphylococcus auras, Escherichia coli, and Pseudomonas aureginosa.