Chronic forms of depression account for approximately one third of all depr
essions. They are underrecognized and undertreated. This article defines th
e types of chronic depressions (dysthymic disorder, double depression, chro
nic major depression, and major depression in incomplete remission). A revi
ew of treatments for patients with these conditions is provided. The basic
principles of treatment of chronic depression involve longer treatment and
higher doses than al e usually required for acute major depression. The imp
act of psychosocial disability and severity of depressive symptoms can be a
meliorated with appropriate treatment. Newer treatments. such as the combin
ation of psychotherapy and pharmacotherapy, may prove to br of greatest ben
efit for individuals with chronic mood disorders.