P. Invernizzi et al., Autoantibodies against nuclear pore complexes are associated with more active and severe liver disease in primary biliary cirrhosis, J HEPATOL, 34(3), 2001, pp. 366-372
Background/Aims: Antibodies against nuclear pore complexes (NPCs) have been
detected in primary biliary cirrhosis (PBC), but their clinical relevance
is still unsettled.
Methods: We tested sera from 171 consecutive PBC patients and 230 control s
ubjects (149 with autoimmune or viral liver diseases, 28 with systemic lupu
s erythematosus, and 53 healthy) by immunoblotting for antibodies against p
urified human NPCs.
Results: Antibodies to NPCs were detected in 27% of the patients with PBC,
were highly specific (97%), and were not associated with antimitochondrial
antibodies. Their prevalence was higher in symptomatic patients (36 vs. 16%
, P < 0.01) and was associated (P < 0.001) with more severe disease, as ass
essed by the presence of cirrhosis of its complications (13% prevalence in
patients without cirrhosis, 31% in uncomplicated, and 54% in complicated ci
rrhosis), or by the application of the Mayo prognostic model (12% in the lo
west, 21% in the median, 47% in the highest score tertile), Positive patien
ts had higher levels of serum bilirubin (2.2 +/- 3.7 vs. 1.0 +/- 1.1 mg/dl,
P < 0.01) and more marked inflammatory infiltrates on liver biopsy (P < 0.
05).
Conclusions: Autoantibodies to NPCs are more prevalent in PBC patients than
in controls and are strongly associated with more active and severe diseas
e.
(C) 2001 European Association for the Study of the Liver. Published by Else
vier Science B.V, All rights reserved.