We consider 'brane universe' scenarios with standard-model fields localized
on a 3-brane in 6 spacetime dimensions. We show that if the spacetime is r
otationally symmetric about the brane, local quantities in the bulk are ins
ensitive to the couplings on the brane. This potentially allows compactific
ations where the effective 4-dimensional cosmological constant is independe
nt of the couplings on the 3-brane. We consider several possible singularit
y-free compactification mechanisms, and find that they do not maintain this
property. We also find solutions with naked spacetime singularities, and w
e speculate that new short-distance physics can become important near the s
ingularities and allow a compactification with the desired properties. The
picture that emerges is that standard-model loop contributions to the effec
tive 4-dimensional cosmological constant can be cut off at distances shorte
r than the compactification scale. At shorter distance scales, renormalizat
ion effects due to standard-model fields renormalize the 3-brane tension, w
hich changes a deficit angle in the transverse space without affecting loca
l quantities in the bulk. For a compactification scale of order 10(-2) mm,
this gives a standard-model contribution to the cosmological constant in th
e range favored by cosmology.