The inhomogeneity of the media or the external forces usually destroy the i
ntegrability of a system. We propose a systematic construction of a class o
f quantum models, which retains their exact integrability inspite of their
explicit inhomogeneity. Such models include variable mass sine-Gordon model
, cylindrical NLS, spin chains with impurity, inhomogeneous Toda chain, the
Ablopiitz-Ladik model etc.