T. Nittoh et al., INCREASE IN EOSINOPHILIC CELL-POPULATION IN BONE-MARROW OF RATS BY IMMUNIZATION WITH ASCARIS-SUUM ANTIGEN, Immunological investigations, 26(4), 1997, pp. 439-451
Immunization of rats with the antigen, Ascaris suum extract, increased
the number of peripheral eosinophils. Analysis by Western blot and re
verse transcription-polymerase chain reaction revealed that the levels
of major basic protein and its mRNA in the bone marrow were also incr
eased, suggesting that eosinophilic cell population in the bone marrow
is increased by the immunization. These findings indicate that immuni
zation with this antigen stimulates differentiation of progenitor cell
s to eosinophils in the bone marrow, and induces blood eosinophilia.