Effect of iron on the virulence of Trichomonas vaginalis

Citation
Js. Ryu et al., Effect of iron on the virulence of Trichomonas vaginalis, J PARASITOL, 87(2), 2001, pp. 457-460
Citations number
29
Categorie Soggetti
Biology,Microbiology
Journal title
JOURNAL OF PARASITOLOGY
ISSN journal
00223395 → ACNP
Volume
87
Issue
2
Year of publication
2001
Pages
457 - 460
Database
ISI
SICI code
0022-3395(200104)87:2<457:EOIOTV>2.0.ZU;2-9
Abstract
The role of iron was evaluated with respect to the virulence of Trichomonus vaginalis in mice. iron-supplemented and iron-depleted Diamond's trypticas e-yeast extract-maltose (TYM) media were prepared by adding 360 muM of ferr ous sulfate and 100 muM of 2,2'-dipyridyl. Trophozoites cultivated from nor mal TYM and iron-supplemented TYM media produced subcutaneous abscesses: ho wever. trichomonads grown in an iron-deficient TYM medium failed to produce any pathology. In addition to the increased virulence of trophozoites in m ice, iron affects the level of adherence and the cytotoxicity of trichomona ds to HeLa cells, which are significantly reduced in trophozoites grown in iron-deficient medium. in conclusion, it is suggested that under iron-deple ted conditions such as that induced by 2,2'-dipyridyl the virulence of T. v aginalis is reduced.