Unrelated umbilical cord stem cell transplantation for X-linked immunodeficiencies

Banked unrelated umbilical cord blood matched at 5 of 6 human leukocyte ant igen loci was used to reconstitute the immune system in 2 brothers with X-l inked lymphoproliferative syndrome and 1 boy with X-linked hyper-immunoglob ulin-M syndrome. Pretransplant cytoreduction and posttransplant graft-versu s-host prophylaxis were given, Hematopoietic engraftment and correction of the genetic defects were documented by molecular techniques. Two years afte r transplantation, all 3 patients have normal immune systems. These reports support the wider use of banked partially matched cord blood for transplan tation in primary immunodeficiencies.