An identifiability analysis of a parent-metabolite pharmacokinetic model for ivabradine

The paper considers the structural identifiability of a parent-metabolite p harmacokinetic model for ivabradine and one of its metabolites. The model, which is linear, is consider ed initially for intravenous administration of ivabradine, and then for a combined intravenous and oral administration. I n both cases, the model is shown to be unidentifiable. Simplification of th e model (for both forms of administration! to that proposed by Duffull et a l. (1) results in a globally structurally identifiable model. The analysis could be applied In the modeling of any drug undergoing first-pass metaboli sm, with plasma concentrations available from drug and metabolite.