Pacing for patients with severe heart failure without bradyarrhythmia has b
een proposed as an addition to medical therapy over the past decade. Altera
tion of the normal electrical activation sequence of the heart modifies its
mechanical action, especially when ventricular function is poor. Both the
site of ventricular-lead placement and timing with the atria have been mani
pulated in attempts to alleviate the symptoms of heart failure. Most recent
ly, in addition to the conventional two leads used for pacing, a third lead
to pace the left ventricle has been advocated in some patients with heart
failure. We review the evidence for pacing in heart failure.